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| Day | Date | Opponent | Location | TV | Outcome/Time |
| Sun | 11/05/2000 | EXHIBITION GAME | Clemson, S.C. | 2:00 PM | |
| Tue | 11/14/2000 | Dynamo Kiev (Exhibition) | Clemson, S.C. | W, 86-71 | |
| Sat | 11/18/2000 | Illinois | Champaign, Ill. | L, 80-62 Recap | Stats | |
| Mon | 11/20/2000 | East Carolina | Clemson, S.C. | W, 92-58 Recap | Stats | |
| Fri | 11/24/2000 | Tennessee (Maui Classic) | Maui, Hawaii (Maui Classic) | L, 86-58 Recap | Stats | |
| Sat | 11/25/2000 | Alcorn State | Maui, Hawaii (Maui Classic) | W, 66-58 Recap | Stats | |
| Wed | 11/29/2000 | South Carolina | Columbia, S.C. | W, 56-43 Recap | Stats | |
| Wed | 12/06/2000 | Furman | Clemson, S.C. | W, 80-59 Recap | Stats | |
| Sat | 12/09/2000 | Duke | Clemson, S.C. | W, 93-75 Recap | Stats | |
| Sat | 12/16/2000 | Nc Greensboro | Clemson, S.C. | W, 89-65 Recap | Stats | |
| Mon | 12/18/2000 | Virginia Tech | Clemson, S.C. | W, 80-59 Recap | Stats | |
| Thu | 12/21/2000 | Auburn | MYRTLE BEACH | W, 72-61 Recap | Stats | |
| Thu | 12/28/2000 | Wofford | Clemson, S.C. | W, 73-63 Recap | Stats | |
| Sat | 12/30/2000 | Winthrop | Rock Hill, SC | W, 79-46 Recap | Stats | |
| Tue | 01/02/2001 | Maryland | College Park, Md. | L, 85-73 Recap | Stats | |
| Fri | 01/05/2001 | No Carolina St | Raleigh, NC | W, 67-52 Recap | Stats | Archived Audio | |
| Mon | 01/08/2001 | North Carolina | Clemson, S.C. | RSN | L, 71-70 Recap | Stats |
| Thu | 01/11/2001 | Wake Forest | Clemson, S.C. | W, 67-45 Recap | Stats | |
| Mon | 01/15/2001 | Virginia | Charlottesville, Va. | TV | W, 87-71 Recap | Stats |
| Thu | 01/18/2001 | Georgia Tech | Atlanta, GA | W, 72-64 Recap | Archived Audio | |
| Sun | 01/21/2001 | Florida State | Clemson, S.C. | W, 79-66 Recap | Stats | |
| Sun | 01/28/2001 | Duke | Durham, NC | TV | L, 92-42 Recap | Archived Audio |
| Thu | 02/01/2001 | Maryland | Clemson, S.C. | L, 68-62 Recap | Stats | Archived Audio | |
| Sun | 02/04/2001 | No Carolina St | Clemson, S.C. | L, 56-50 Recap | Stats | |
| Thu | 02/08/2001 | North Carolina | Chapel Hill, N.C. | L, 100-99 Recap | Archived Audio | |
| Sun | 02/11/2001 | Wake Forest | Winston-Salem, N.C. | RSN | W, 72-55 Recap | Archived Audio |
| Thu | 02/15/2001 | Virginia | Clemson, S.C. | W, 78-71 Recap | Stats | Archived Audio | |
| Mon | 02/19/2001 | Georgia Tech | Clemson, S.C. | W, 68-49 Recap | Stats | Archived Audio | |
| Thu | 02/22/2001 | Florida State | Tallahassee, FL | W, 63-49 Recap | Archived Audio | |
| Sat | 03/03/2001 | North Carolina | Greensboro, NC | W, 75-57 Recap | Stats | Quotes | |
| Sun | 03/04/2001 | No Carolina St | Greensboro, NC | TV | L, 65-52 Recap | Stats | Quotes | FANSlive GameTracker |
| Fri | 03/16/2001 | Tenn Chattanooga | Cincinnati, Ohio | W, 51-49 Recap | Stats | Archived Audio | |
| Sun | 03/18/2001 | Xavier/Louis. Winner (NCAA Second Round) | Cincinnati, Ohio | L, 77-62 Recap | Stats | Archived Audio |
