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| Date | Day | Opponent | Location | Outcome/Time |
| 08/26/2000 | Sat | Connecticut | Storrs, Conn. | 2:00 PM ET |
| 09/03/2000 | Sun | Hartford (BI-LO Kickoff Classic) | Clemson, S.C. | W, 4-0 Recap |
| 09/06/2000 | Wed | Wofford | Spartanburg, S.C. | W, 4-0 Recap |
| 09/10/2000 | Sun | North Carolina | Clemson, S.C. | L, 2-1 Recap |
| 09/14/2000 | Thu | Appalachian State | Clemson, S.C. | W, 4-0 Recap |
| 09/17/2000 | Sun | Duke | Durham, N.C. | L, 3-2 Recap |
| 09/20/2000 | Wed | Charleston Southern | Clemson, S.C. | W, 6-1 Recap |
| 09/24/2000 | Sun | North Carolina State | Clemson, S.C. | W, 6-1 Recap |
| 09/29/2000 | Fri | Brown (Nike Invitational) | Clemson, S.C. | W, 2-1 Recap |
| 10/01/2000 | Sun | Cal St.-Fullerton (Nike Invitational) | Clemson, S.C. | W, 5-1 Recap |
| 10/08/2000 | Sun | South Carolina | Columbia, S.C. | T, 0-0 Recap |
| 10/11/2000 | Wed | Georgia State | Clemson, S.C. | W, 3-1 Recap |
| 10/15/2000 | Sun | Virginia | Clemson, S.C. | L, 3-2 Recap |
| 10/18/2000 | Wed | Davidson | Davidson, N.C. | W, 3-2 Recap |
| 10/21/2000 | Sat | Wake Forest | Winston-Salem, N.C. | W, 2-1 Recap |
| 10/25/2000 | Wed | Furman | Clemson, S.C. | W, 2-0 Recap |
| 10/28/2000 | Sat | Maryland | College Park, Md. | W, 3-2 Recap |
| 11/05/2000 | Sun | UNC-Charlotte | Charlotte, N.C. | W, 4-0 Recap |
| 11/09/2000 | Thu | A.C.C. Tournament | Winston-Salem, N.C. | T, 2-2 Recap |
| 11/19/2000 | Sun | Furman (NCAA First Round) | Clemson, S.C. | W, 3-2 Recap |
| 11/26/2000 | Sun | Connecticut (NCAA 2nd Round) | Clemson, S.C. | L, 2-1 (OT) Recap | Quotes |
