| WEB |
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| Date | Day | Opponent | Location | TV | Outcome/Time |
| 09/02/2000 | Sat | The Citadel (IPTAY/Tiger Cub Day) | Clemson, S.C. | W, 38-0 Recap | Stats | Archived Audio | |
| 09/09/2000 | Sat | Missouri (Hall of Fame Day) | Clemson, S.C. | ABC Regional | W, 62-9 Recap | Stats | Archived Audio |
| 09/16/2000 | Sat | Wake Forest (Youth Day) | Clemson, S.C. | W, 55-7 Recap | Stats | Archived Audio | |
| 09/23/2000 | Sat | Virginia | Charlottesville, Va. | ABC Regional | W, 31-10 Recap | Stats | Archived Audio |
| 09/30/2000 | Sat | Duke | Durham, N.C. | JP-TV | W, 52-22 Recap | Stats | Notes | Archived Audio |
| 10/07/2000 | Sat | North Carolina State (Textile Bowl/Bowl Reunion Day) | Clemson, S.C. | ABC Regional | W, 34-27 Recap | Stats | Archived Audio | FANSlive GameTracker |
| 10/14/2000 | Sat | Maryland (Homecoming/Parents' Weekend) | Clemson, S.C. | ESPN2 | W, 35-14 Recap | Stats | Archived Audio |
| 10/21/2000 | Sat | North Carolina | Chapel Hill, N.C. | ESPN2 | W, 38-24 Recap | Stats | Archived Audio |
| 10/28/2000 | Sat | Georgia Tech (Tiger Pride Day) | Clemson, S.C. | ABC | L, 31-28 Recap | Stats | Archived Audio |
| 11/04/2000 | Sat | Florida State | Tallahassee, Fla. | ESPN | L, 54-7 Recap | Stats | Archived Audio |
| 11/18/2000 | Sat | South Carolina | Clemson, S.C. | ABC | W, 16-14 Recap | Stats | Archived Audio |
| 01/01/2001 | Mon | Virginia Tech Gator Bowl | Jacksonville, Fla. | NBC | L, 41-20 Recap | Stats | Archived Audio |
