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| Day | Date | Opponent | Location | TV | Outcome/Time |
| Thu | 11/02/2000 | California All-Stars | Clemson, S.C. | 7:30 PM | |
| Thu | 11/09/2000 | Latvia Club Ventspils | Clemson, S.C. | L, 113-104 Recap | Stats | |
| Fri | 11/17/2000 | Hartford | Clemson, S.C. | W, 86-67 Recap | Stats | Archived Audio | |
| Tue | 11/21/2000 | Seton Hall | Clemson, S.C. | FSNS | L, 79-78 Recap | Stats | Archived Audio |
| Sat | 11/25/2000 | The Citadel | Clemson, S.C. | FSNS/SUN | W, 84-76 Recap | Stats | Archived Audio |
| Tue | 11/28/2000 | Northwestern | Clemson, S.C. | ESPN2 | W, 57-44 Recap | Stats | Archived Audio |
| Sat | 12/02/2000 | Westrn Carolina | Clemson, S.C. | W, 87-52 Recap | Stats | Archived Audio | |
| Tue | 12/05/2000 | Winthrop | Clemson, S.C. | W, 69-59 Recap | Stats | Archived Audio | |
| Sat | 12/09/2000 | South Carolina | Columbia, S.C. | FSNS/SUN | L, 76-64 Recap | Stats | Archived Audio |
| Sat | 12/16/2000 | Wofford | Clemson, S.C. | W, 78-74 Recap | Stats | Archived Audio | |
| Wed | 12/20/2000 | Florida Atlantic | San Juan, Puerto Rico | W, 94-81 Recap | Stats | Archived Audio | |
| Thu | 12/21/2000 | Cincinnati | San Juan, Puerto Rico | L, 88-80 Recap | Stats | Archived Audio | |
| Fri | 12/22/2000 | Washington | San Juan, Puerto Rico | L, 77-76 Recap | Stats | Audio Broadcast | |
| Thu | 12/28/2000 | Charleston Southern | Clemson, S.C. | W, 87-77 Recap | Stats | Archived Audio | |
| Sat | 12/30/2000 | Coastal Carolina | Conway, S.C. | W, 81-68 Recap | Stats | Archived Audio | |
| Tue | 01/02/2001 | Maryland | Clemson, S.C. | RJ | L, 104-92 Recap | Stats | Archived Audio |
| Sun | 01/07/2001 | Duke | Durham, N.C. | RJ | L, 115-74 Recap | Stats | Archived Audio |
| Sat | 01/13/2001 | No Carolina St | Clemson, S.C. | RJ | W, 72-69 Recap | Stats | Archived Audio |
| Wed | 01/17/2001 | North Carolina | Chapel Hill, N.C. | ESPN | L, 92-65 Recap | Stats | Archived Audio |
| Sun | 01/21/2001 | Wake Forest | Winston-Salem, N.C. | R-J | L, 71-63 Recap | Stats | Archived Audio |
| Wed | 01/24/2001 | Georgia Tech | Clemson, S.C. | L, 111-108 Recap | Stats | Archived Audio | |
| Sat | 01/27/2001 | Virginia | Clemson, S.C. | L, 104-76 Recap | Stats | Archived Audio | |
| Wed | 01/31/2001 | Florida State | Tallahassee, Fla. | L, 88-84 Recap | Stats | Archived Audio | |
| Sun | 02/04/2001 | Maryland | College Park, Md. | RJ | L, 69-54 Recap | Stats | Archived Audio | FANSlive GameTracker |
| Wed | 02/07/2001 | Duke | Clemson, S.C. | ESPN | L, 81-64 Recap | Stats | Archived Audio |
| Wed | 02/14/2001 | No Carolina St | Raleigh, N.C. | RJ-Split | L, 85-51 Recap | Stats | Archived Audio |
| Sun | 02/18/2001 | North Carolina | Clemson, S.C. | RJ | W, 75-65 Recap | Stats | Notes | Archived Audio |
| Wed | 02/21/2001 | Wake Forest | Clemson, S.C. | L, 92-60 Recap | Stats | Archived Audio | |
| Sun | 02/25/2001 | Georgia Tech | Atlanta, Ga. | RJ-Split | L, 85-64 Recap | Stats | Archived Audio |
| Wed | 02/28/2001 | Virginia | Charlottesville, Va. | L, 84-65 Recap | Stats | Archived Audio | |
| Sat | 03/03/2001 | Florida State | Clemson, S.C. | Sports Net South/HTS/Sun | L, 75-63 Recap | Stats | Archived Audio |
| Thu | 03/08/2001 | Florida State | Atlanta | RJ/ESPN | W, 66-64 Recap | Stats | Quotes | Archived Audio | FANSlive GameTracker |
| Fri | 03/09/2001 | North Carolina (ACC Tournament Quarterfinals) | Atlanta | RJ/ESPN | L, 99-81 Recap | Stats | Quotes | Archived Audio | FANSlive GameTracker |
