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| Day | Date | Opponent | Location | Outcome/Time |
| Fri | 11/05/1999 | California South All-Stars | Clemson, S.C. | 7:00 PM ET |
| Tue | 11/09/1999 | Down Under Bandits | Clemson, S.C. | W, 85-62 Recap |
| Fri | 11/19/1999 | East Tennessee St. | Clemson, S.C. | W, 77-47 Recap | Stats |
| Sun | 11/21/1999 | Wofford | Clemson, S.C. | L, 79-74 Recap | Stats |
| Fri | 11/26/1999 | Central Florida | Greenville, S.C. (SoCon Holiday Hoops) | W, 54-48 Recap | Stats |
| Sat | 11/27/1999 | Wisconsin-Green Bay | Greenville, S.C. (SoCon Holiday Hoops) | L, 64-47 Recap | Stats |
| Sun | 11/28/1999 | Oregon State | Greenville, S.C. (SoCon Holiday Hoops Tournament) | L, 53-35 Recap | Stats |
| Wed | 12/01/1999 | Penn State | University Park, Pa. | L, 85-75 Recap | Stats |
| Sat | 12/04/1999 | Charleston Southern | Clemson, S.C. | W, 69-51 Recap | Stats |
| Sat | 12/11/1999 | S.C. State | Clemson, S.C. | L, 71-68 Recap | Stats |
| Thu | 12/16/1999 | South Carolina | Clemson, S.C. | W, 61-58 Recap | Stats | Notes |
| Sat | 12/18/1999 | Winthrop | Clemson, S.C. | W, 64-59 Recap | Stats | Notes |
| Wed | 12/22/1999 | George Washington | Clemson, S.C. | L, 90-71 Recap | Stats | Notes |
| Wed | 12/29/1999 | Furman | Greenville, S.C. (BiLo Center) | W, 74-70 Recap | Stats |
| Thu | 01/06/2000 | North Carolina* | Chapel Hill, N.C. | L, 65-45 Recap | Stats |
| Sun | 01/09/2000 | Wake Forest* | Clemson, S.C. | L, 67-53 Recap | Stats | Quotes | Notes |
| Wed | 01/12/2000 | Florida State* | Tallahassee, Fla. | L, 60-57 Recap | Stats |
| Sat | 01/15/2000 | Virginia* | Clemson, S.C. | L, 98-91 Recap | Stats | Quotes | Notes |
| Wed | 01/19/2000 | Appalachian State | Clemson, S.C. | L, 72-60 Recap | Stats | Quotes | Notes |
| Sat | 01/22/2000 | Maryland* | College Park, Md. | L, 74-62 Recap | Stats |
| Thu | 01/27/2000 | N.C. State* | Clemson, S.C. | W, 59-42 Recap | Stats | Quotes | Notes |
| Sat | 01/29/2000 | Duke* | Durham, N.C. | L, 93-59 Recap | Stats |
| Wed | 02/02/2000 | Georgia Tech* | Clemson, S.C. | W, 70-58 Recap | Stats | Quotes | Notes |
| Sun | 02/06/2000 | North Carolina* | Clemson, S.C. | L, 73-60 Recap | Stats | Quotes | Notes |
| Tue | 02/08/2000 | Wake Forest* | Winston-Salem, N.C. | L, 79-63 Recap | Stats |
| Sat | 02/12/2000 | Florida State* | Clemson, S.C. | W, 84-58 Recap | Stats | Quotes | Notes |
| Tue | 02/15/2000 | Virginia* | Charlottesville, Va. | L, 76-62 Recap | Stats |
| Tue | 02/22/2000 | Maryland* | Clemson, S.C. | L, 76-63 Recap | Stats | Notes |
| Sun | 02/27/2000 | N.C. State* | Raleigh, N.C. | W, 66-63 Recap | Stats |
| Wed | 03/01/2000 | Duke* | Clemson, S.C. | L, 92-78 Recap | Stats | Quotes | Notes |
| Sat | 03/04/2000 | Georgia Tech* | Atlanta, Ga. | L, 85-69 Recap | Stats |
| Thu | 03/09/2000 | Duke | Charlotte, N.C. (ACC Tournament - 1st Round) | L, 94-63 Recap | Stats |
