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| Date | Day | Opponent | Location | TV | Outcome/Time |
| 02/16/2001 | Fri | Richmond | Clemson, SC | L, 10-5 Recap | Stats | |
| 02/17/2001 | Sat | Richmond | Clemson, SC | WGOG WCSZ | W, 14-4 Recap | Stats |
| 02/18/2001 | Sun | Richmond | Clemson, SC | WCSZ | W, 7-3 Recap | Stats |
| 02/22/2001 | Thu | at UNLV | Las Vegas, NV | W, 10-6 Recap | Stats | |
| 02/23/2001 | Fri | Oregon State | Las Vegas, NV | W, 9-5 Recap | Stats | |
| 02/23/2001 | Fri | at UNLV | Las Vegas, NV | L, 14-6 Recap | Stats | |
| 02/24/2001 | Sat | Oregon State | Las Vegas, Nev. | L, 10-9 Recap | Stats | |
| 02/25/2001 | Sun | Oregon St. | Las Vegas, NV | W, 13-2 Recap | Stats | |
| 02/28/2001 | Wed | Furman | Clemson, SC | WCSZ | W, 7-4 Recap | Stats |
| 03/03/2001 | Sat | South Carolina | Clemson, SC | CTN | L, 21-8 Recap | Stats | Archived Audio |
| 03/04/2001 | Sun | at South Carolina | Columbia, SC | W, 7-4 Recap | Stats | |
| 03/07/2001 | Wed | College of Charleston | Clemson, SC | WCSZ | W, 5-3 Recap | Stats |
| 03/10/2001 | Sat | Ohio | Clemson, SC | WGOG | W, 5-2 Recap | Stats |
| 03/11/2001 | Sun | Ohio | Clemson, SC | WGOG | W, 17-4 Recap | Stats |
| 03/13/2001 | Tue | GEORGIA SOUTHERN | Clemson, SC | WGOG | L, 12-9 Recap | Stats |
| 03/14/2001 | Wed | GEORGIA SOUTHERN | Clemson, SC | WCSZ | W, 9-3 Recap | Stats |
| 03/16/2001 | Fri | *at Maryland | College Park, MD | W, 8-6 Recap | Stats | |
| 03/17/2001 | Sat | *at Maryland | College Park, MD | W, 9-6 Stats | |
| 03/18/2001 | Sun | *at Maryland | College Park, MD | W, 7-0 Recap | Stats | |
| 03/20/2001 | Tue | at Old Dominion | Norfolk, VA | W, 11-1 Recap | Stats | |
| 03/21/2001 | Wed | at Old Dominion | Norfolk, VA | L, 10-8 Recap | Stats | |
| 03/23/2001 | Fri | *Wake Forest | Winston Salem, N.C. | CTN | W, 4-1 Recap | Stats | Archived Audio |
| 03/24/2001 | Sat | *Wake Forest | Winston Salem, N.C. | CTN | L, 12-3 Recap | Stats | Archived Audio |
| 03/25/2001 | Sun | *Wake Forest | Winston Salem, N.C. | CTN | W, 9-1 Recap | Stats | Archived Audio |
| 03/27/2001 | Tue | WOFFORD | Clemson, SC | WGOG WCSZ | W, 6-0 Recap | Stats |
| 03/28/2001 | Wed | at Georgia | Athens, GA | CTN | L, 8-4 Recap | Stats | Archived Audio |
| 03/30/2001 | Fri | NEW YORK TECH | Clemson, SC | CTN | W, 24-3 Recap | Stats | Archived Audio |
| 03/31/2001 | Sat | NEW YORK TECH | Clemson, SC | CTN | W, 13-0 Recap | Stats | Live Audio |
| 03/31/2001 | Sat | NEW YORK TECH | Clemson, SC | CTN | W, 14-0 Recap | Stats | Archived Audio |
| 04/03/2001 | Tue | Westrn Carolina | Cullowhee, NC | 3:00 PM ET | |
| 04/04/2001 | Wed | WINTHROP | Clemson, SC | CTN | L, 8-4 Recap | Stats | Archived Audio |
| 04/06/2001 | Fri | *Florida State | Tallahassee, Fla. | CTN | L, 7-4 Recap | Stats | Archived Audio |
| 04/07/2001 | Sat | *Florida State | Tallahassee, Fla. | CTN SUN | L, 7-6 Recap | Stats | Archived Audio |
| 04/08/2001 | Sun | *Florida State | Tallahassee, Fla. | CTN | L, 6-1 Recap | Stats | Archived Audio |
| 04/10/2001 | Tue | COASTAL CAROLINA | Clemson, SC | L, 10-5 Recap | Stats | |
| 04/11/2001 | Wed | COASTAL CAROLINA | Clemson, SC | CTN | W, 8-7 Recap | Stats | Archived Audio |
| 04/13/2001 | Fri | *DUKE | Clemson, SC | CTN | W, 10-2 Recap | Stats | Archived Audio |
| 04/14/2001 | Sat | *DUKE | Clemson, SC | CTN CSSE | W, 10-1 Recap | Stats | Archived Audio |
| 04/15/2001 | Sun | *DUKE | Clemson, SC | CTN | W, 6-4 Recap | Stats | Archived Audio |
| 04/17/2001 | Tue | GEORGIA | Clemson, SC | CTN CSSE | W, 10-4 Recap | Stats | Archived Audio |
| 04/18/2001 | Wed | at South Carolina | Columbia, SC | CTN | L, 9-3 Recap | Stats | Archived Audio |
| 04/20/2001 | Fri | *GEORGIA TECH | Clemson, SC | CTN | W, 3-0 Stats | Archived Audio |
| 04/21/2001 | Sat | *GEORGIA TECH | Clemson, SC | CTN CSSE | W, 5-1 Recap | Stats | Archived Audio |
| 04/22/2001 | Sun | *GEORGIA TECH | Clemson, SC | CTN | L, 5-3 Recap | Stats | Archived Audio |
| 04/24/2001 | Tue | Westrn Carolina | Clemson, SC | W, 8-2 Recap | Stats | |
| 04/25/2001 | Wed | SOUTH CAROLINA | Clemson, SC | CTN CSSE | L, 2-1 Recap | Stats | Archived Audio |
| 04/27/2001 | Fri | *North Carolina | Clemson, S.C. | CTN | W, 6-3 Recap | Stats | Archived Audio |
| 04/28/2001 | Sat | *North Carolina | Clemson, S.C. | CTN CSSE | W, 10-9 (10) Recap | Stats | Archived Audio |
| 04/29/2001 | Sun | *North Carolina | Clemson, S.C. | CTN | L, 4-0 Recap | Stats | Archived Audio |
| 05/05/2001 | Sat | *at N.C. State | Raleigh, NC | CTN ACCTV | W, 7-6 Recap | Stats | Archived Audio |
| 05/05/2001 | Sat | *at N.C. State | Raleigh, NC | CTN | L, 4-3 Recap | Stats | Archived Audio |
| 05/06/2001 | Sun | *at N.C. State | Raleigh, NC | CTN | W, 10-2 Recap | Stats | Archived Audio |
| 05/09/2001 | Wed | at Furman | Greenville, SC | CTN | W, 9-6 Recap | Archived Audio |
| 05/12/2001 | Sat | *VIRGINIA | Clemson, SC | CTN ACCTV | W, 8-1 Recap | Stats | Archived Audio |
| 05/12/2001 | Sat | * Virginia | Clemson, SC | W, 17-1 Recap | Stats | |
| 05/13/2001 | Sun | *VIRGINIA | Clemson, SC | CTN CSSE | W, 5-4 Recap | Stats | Archived Audio |
| 05/16/2001 | Wed | Virginia | Fort Mill, SC | CTN | L, 7-3 Recap | Stats | Archived Audio |
| 05/17/2001 | Thu | North Carolina (ACC Tournament) | Fort Mill, SC | CTN | W, 7-6 Recap | Stats | Archived Audio |
| 05/18/2001 | Fri | Florida State (ACC Tournament) | Fort Mill, SC | CTN | L, 5-4 Recap | Stats | Archived Audio |
| 05/25/2001 | Fri | William & Mary (NCAA Regionals) | Clemson, SC | CTN | W, 4-1 Recap | Stats | Archived Audio |
| 05/26/2001 | Sat | Seton Hall (NCAA Regionals) | Clemson, SC | CTN | W, 24-4 Recap | Stats | Archived Audio |
| 05/27/2001 | Sun | Seton Hall (NCAA Regionals) | Clemson, SC | CTN | W, 8-2 Recap | Stats | Archived Audio |
| 06/01/2001 | Fri | Miami (NCAA Super Regional) | Coral Gables, Fla. | L, 10-8 Recap | Stats | Quotes | Notes | |
| 06/02/2001 | Sat | Miami (NCAA Super Regional) | Coral Gables, Fla. | CTN | L, 14-6 Recap | Stats | Archived Audio | Live Box Score |
| 06/08/2001 | Fri | College World Series | Omaha, NE | CTN | TBA |
| 06/09/2001 | Sat | College World Series | Omaha, NE | CTN | TBA |
| 06/10/2001 | Sun | College World Series | Omaha, NE | CTN | TBA |
| 06/11/2001 | Mon | College World Series | Omaha, NE | CTN | TBA |
| 06/12/2001 | Tue | College World Series | Omaha, NE | CTN | TBA |
| 06/13/2001 | Wed | College World Series | Omaha, NE | CTN | TBA |
| 06/14/2001 | Thu | College World Series | Omaha, NE | CTN | TBA |
| 06/15/2001 | Fri | College World Series | Omaha, NE | CTN | TBA |
| 06/16/2001 | Sat | College World Series | Omaha, NE | CTN | TBA |
